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CBF changes in drug naive juvenile myoclonic epilepsy patients

Title
CBF changes in drug naive juvenile myoclonic epilepsy patients
Authors
Tae W.S.Joo E.Y.Han S.J.Lee K.-H.Hong S.B.
Ewha Authors
주은연
Issue Date
2007
Journal Title
Journal of Neurology
ISSN
0340-5354JCR Link
Citation
vol. 254, no. 8, pp. 1073 - 1080
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Purpose: The role of thalamus and brainstem in generalized epilepsy has been suggested in previous studies. The aim of the present study was to assess regional cerebral blood flow (rCBF) abnormality in juvenile myoclonic epilepsy (JME) patients. Methods: 99mTc-ethylcysteinate dimer brain single photon emission computed tomography (SPECT) was performed in 19 drug naive JME patients and 25 normal controls with the similar age and gender distribution. Differences of rCBF between a JME group and a normal control group were examined by the statistical parametric mapping of brain SPECT images using independent t test. The regression analyses in SPM were also performed between rCBF and the age of seizure onset or the disease duration in JME group. Results: Compared to normal controls, the JME group showed a significant rCBF reduction in bilateral thalami, red nucleus, midbrain, pons, left hippocampus, and in the cerebelli (FDR corrected p < 0.01) whereas rCBF increase in the left superior frontal gyrus (uncorrected p < 0.001 but FDR corrected p > 0.05). Disease duration was negatively correlated with rCBF in bilateral frontal cortices, caudate nuclei, brainstem and cerebellar tonsils. Conclusions: Our results suggest that abnormal neural networks in the thalamus, hippocampus, brainstem and cerebellum are associated with JME. © 2007 Steinkopff-Verlag.
DOI
10.1007/s00415-006-0491-6
Appears in Collections:
의과대학 > 의학과 > Journal papers
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