Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.date.accessioned | 2017-02-15T08:02:28Z | - |
dc.date.available | 2017-02-15T08:02:28Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 1071-5762 | * |
dc.identifier.other | OAK-4115 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234387 | - |
dc.description.abstract | The present study investigated the cytoprotective properties of glycitein, a metabolite formed by the transformation of glycitin by intestinal microflora, against oxidative stress. Glycitein was found to scavenge intracellular reactive oxygen species (ROS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and thereby preventing lipid peroxidation and DNA damage. Glycitein inhibited apoptosis of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O2) via radical scavenging activity. Glycitein abrogated the activation of c-Jun N-terminal kinase (JNK) induced by H2O2 treatment and inhibited DNA binding activity of activator protein-1 (AP-1), a downstream transcription factor of JNK. Taken together, these findings suggest that glycitein protected H2O2 induced cell death in V79-4 cells by inhibiting ROS generation and JNK activation. | * |
dc.language | English | * |
dc.title | Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 41 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 720 | * |
dc.relation.lastpage | 729 | * |
dc.relation.journaltitle | Free Radical Research | * |
dc.identifier.doi | 10.1080/10715760701241618 | * |
dc.identifier.wosid | WOS:000247875900013 | * |
dc.identifier.scopusid | 2-s2.0-34249824273 | * |
dc.author.google | Kang K.A. | * |
dc.author.google | Zhang R. | * |
dc.author.google | Piao M.J. | * |
dc.author.google | Lee K.H. | * |
dc.author.google | Kim B.J. | * |
dc.author.google | Kim S.Y. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Kim D.H. | * |
dc.author.google | You H.J. | * |
dc.author.google | Hyun J.W. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.date.modifydate | 20240118140922 | * |