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Discovery of gliotoxin as a new small molecule targeting thioredoxin redox system

Title
Discovery of gliotoxin as a new small molecule targeting thioredoxin redox system
Authors
Choi H.S.Shim J.S.Kim J.-A.Kang S.W.Kwon H.J.
Ewha Authors
강상원
SCOPUS Author ID
강상원scopus
Issue Date
2007
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 359, no. 3, pp. 523 - 528
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Thioredoxin redox system has been implicated as an intracellular anti-oxidant defense system leading to reduction of cellular oxidative stresses utilizing electrons from NADPH. From high content screening of small molecules targeting the system, gliotoxin, a fungal metabolite, was identified as an active compound. Gliotoxin potently accelerates NADPH oxidation and reduces H2O2. The compound reduces H2O2 to H2O by replacing the function of peroxiredoxin in vitro and decreases intracellular level of H2O2 in HeLa cells. The anti-oxidant activity of gliotoxin was further validated H2O2-mediated cellular phenotype of angiogenesis. The proliferation of endothelial cells was inhibited by the compound at nanomolar range. In addition, H2O2-induced tube formation and invasion of the cells were blocked by gliotoxin. Together, these results demonstrate that gliotoxin is a new small molecule targeting thioredoxin redox system. © 2007 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bbrc.2007.05.139
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자연과학대학 > 생명과학전공 > Journal papers
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