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Cytoprotective effects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1

Title
Cytoprotective effects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1
Authors
Kang K.A.Lee K.H.Kim S.Y.Kim H.S.Kim J.S.Hyun J.W.
Ewha Authors
김희선
SCOPUS Author ID
김희선scopus
Issue Date
2007
Journal Title
Biological and Pharmaceutical Bulletin
ISSN
0918-6158JCR Link
Citation
vol. 30, no. 5, pp. 852 - 858
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The present study investigated the potential cytoprotective properties of a combination of plant extracts (KIOM-79) obtained from Magnolia officinalis, Pueraria lobata, Glycyrrhiza uralensis, and Euphorbia pekinensis, against the oxidative stresses induced by streptozotocin (STZ) in a rat pancreatic β-cells (RINm5F). KIOM-79 was found to scavenge intracellular reactive oxygen species (ROS), thereby preventing DNA damage and lipid peroxidation. The KIOM-79 inhibited apoptosis of the β-cells exposed to STZ via radical scavenging activity and activation of antioxidant enzymes. KIOM-79 inhibited activation of extracellular regulated kinase (ERK) induced by STZ and inhibited DNA binding activity of an activator protein-1 (AP-1), a downstream transcription factor of ERK. Taken together, these findings suggest that KIOM-79 protects against STZ induced cell death in RINm5F cells by inhibiting ROS generation and the ERK pathway. © 2007 Pharmaceutical Society of Japan.
DOI
10.1248/bpb.30.852
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의과대학 > 의학과 > Journal papers
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