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Injectable gel with synthetic collagen-binding peptide for enhanced osteogenesis in vitro and in vivo

Title
Injectable gel with synthetic collagen-binding peptide for enhanced osteogenesis in vitro and in vivo
Authors
Lee J.-Y.Choo J.-E.Park H.-J.Park J.-B.Lee S.-C.Jo I.Lee S.-J.Chung C.-P.Park Y.-J.
Ewha Authors
이승진조인호
SCOPUS Author ID
이승진scopus; 조인호scopus
Issue Date
2007
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 357, no. 1, pp. 68 - 74
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A synthetic peptide denoted as collagen-binding motif (CBM) was identified from osteopontin (OPN), a multisubunit extracellular matrix (ECM) protein, by enzymatic digestion with chymotrypsin. The aim of this study was to examine the feasibility of identified CBM peptide as an active component of gel type scaffold material in osteogenesis. The binding of CBM peptide to collagen was specific and presented high affinity. Cell adhesion and growth on CBM peptide-immobilized gel were significantly increased as compared with those on gel with control peptide or without peptide. The CBM peptide-immobilized gel increased osteoblastic differentiation, followed by marked bone formation in the rabbit calvarial defect sites at 4 weeks. Taken together, the injectable gel with synthetic CBM peptide has a potential to induce osteogenesis in vitro and in vivo, suggesting its clinical application in bone regeneration procedure. © 2007 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bbrc.2007.03.106
Appears in Collections:
약학대학 > 약학과 > Journal papers
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