Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍영미 | * |
dc.date.accessioned | 2017-02-15T08:02:13Z | - |
dc.date.available | 2017-02-15T08:02:13Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0031-3998 | * |
dc.identifier.other | OAK-3966 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234310 | - |
dc.description.abstract | Kawasaki disease (KD) is an acute febrile vasculitic syndrome of unknown etiology that preferentially affects the coronary artery. Interleukin-10 (IL-10) is a key proinflammatory cytokine, and a polymorphism near the major transcriptional start site of the IL-10 gene was shown to influence IL-10 production in vitro. This study investigated the association of the IL-10 promoter polymorphism with KD and its clinical parameters in Korean children. A total of 194 children with congenital heart disease (CHD) and 95 children with KD were included in this study. IL-10 (-627 A/C) polymorphism genotypes were determined using the single-base extension method. There was no difference in the allele frequencies of IL-10 (-627 A/C) polymorphism between CHD children and KD children. KD children with one or two copies of the IL-10 (-627C) allele showed significantly lower albumin levels (p = 0.020) and higher frequencies of early coronary artery aneurysm [62.22% versus 37.78%, adjusted odds ratio (aOR) = 3.50, 95% confidence interval (CI): 1.50-8.16] compared with KD children with the common IL-10 (-627A) allele. These findings suggest that the IL-10 (-627 A/C) promoter polymorphism might be a genetic marker for the risk of early coronary artery complication in KD. © International Pediatrics Research Foundation, Inc. 2007. All Rights Reserved. | * |
dc.language | English | * |
dc.title | The IL-10 (-627 A/C) promoter polymorphism may be associated with coronary aneurysms and low serum albumin in Korean children with Kawasaki disease | * |
dc.type | Article | * |
dc.relation.issue | 5 PART 1 | * |
dc.relation.volume | 61 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 584 | * |
dc.relation.lastpage | 587 | * |
dc.relation.journaltitle | Pediatric Research | * |
dc.identifier.doi | 10.1203/pdr.0b013e3180459fb5 | * |
dc.identifier.wosid | WOS:000246005100013 | * |
dc.identifier.scopusid | 2-s2.0-34247514244 | * |
dc.author.google | Jin H.-S. | * |
dc.author.google | Kim H.B. | * |
dc.author.google | Kim B.S. | * |
dc.author.google | Lee J.-K. | * |
dc.author.google | Seo E.-J. | * |
dc.author.google | Yoo H.-W. | * |
dc.author.google | Park I.S. | * |
dc.author.google | Hong Y.M. | * |
dc.author.google | Hong S.-J. | * |
dc.contributor.scopusid | 홍영미(35210025100;55841904000;56063366100) | * |
dc.date.modifydate | 20240415130647 | * |