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The IL-10 (-627 A/C) promoter polymorphism may be associated with coronary aneurysms and low serum albumin in Korean children with Kawasaki disease

Title
The IL-10 (-627 A/C) promoter polymorphism may be associated with coronary aneurysms and low serum albumin in Korean children with Kawasaki disease
Authors
Jin H.-S.Kim H.B.Kim B.S.Lee J.-K.Seo E.-J.Yoo H.-W.Park I.S.Hong Y.M.Hong S.-J.
Ewha Authors
홍영미
SCOPUS Author ID
홍영미scopus
Issue Date
2007
Journal Title
Pediatric Research
ISSN
0031-3998JCR Link
Citation
vol. 61, no. 5 PART 1, pp. 584 - 587
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Kawasaki disease (KD) is an acute febrile vasculitic syndrome of unknown etiology that preferentially affects the coronary artery. Interleukin-10 (IL-10) is a key proinflammatory cytokine, and a polymorphism near the major transcriptional start site of the IL-10 gene was shown to influence IL-10 production in vitro. This study investigated the association of the IL-10 promoter polymorphism with KD and its clinical parameters in Korean children. A total of 194 children with congenital heart disease (CHD) and 95 children with KD were included in this study. IL-10 (-627 A/C) polymorphism genotypes were determined using the single-base extension method. There was no difference in the allele frequencies of IL-10 (-627 A/C) polymorphism between CHD children and KD children. KD children with one or two copies of the IL-10 (-627C) allele showed significantly lower albumin levels (p = 0.020) and higher frequencies of early coronary artery aneurysm [62.22% versus 37.78%, adjusted odds ratio (aOR) = 3.50, 95% confidence interval (CI): 1.50-8.16] compared with KD children with the common IL-10 (-627A) allele. These findings suggest that the IL-10 (-627 A/C) promoter polymorphism might be a genetic marker for the risk of early coronary artery complication in KD. © International Pediatrics Research Foundation, Inc. 2007. All Rights Reserved.
DOI
10.1203/pdr.0b013e3180459fb5
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의학전문대학원 > 의학과 > Journal papers
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