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Matrix metalloproteinase-1 promoter polymorphism and epithelial ovarian cancer: Does ethnicity matter?

Title
Matrix metalloproteinase-1 promoter polymorphism and epithelial ovarian cancer: Does ethnicity matter?
Authors
Ju W.Kim J.W.Park N.-H.Song Y.-S.Kim S.-C.Kang S.-B.Lee H.-P.
Ewha Authors
김승철주웅
SCOPUS Author ID
김승철scopus; 주웅scopus
Issue Date
2007
Journal Title
Journal of Obstetrics and Gynaecology Research
ISSN
1341-8076JCR Link
Citation
vol. 33, no. 2, pp. 155 - 160
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Aim: To estimate the relationship between matrix metalloproteinase (MMP)-1 promoter -1607 bp polymorphism and the risk of epithelial ovarian cancer (EOC) in Korean women and to clarify the ethnic difference in genotype distribution of this polymorphism. Methods: Single nucleotide polymorphism (SNP) of MMP-1 promoter -1607 region in 133 EOC patients and 332 cancer-free patients were investigated. Then the associations of this polymorphism with EOC or its clinicopathological parameters were analyzed. In addition, genotype distributions of this polymorphism in Korean women were compared with those of other races by extracting data from the previously published literature. Results: We found no relationship between MMP-1 promoter -1607 bp polymorphism and epithelial ovarian cancer in a Korean population. Furthermore, we found ethnicity-dependent differences in genotype distributions and allele frequencies by comparison with previous articles on this topic. We report significant ethnic differences in the genotype distributions and allele frequencies of the MMP-1 promoter -1607 bp polymorphism. Conclusion: Our results indicate that MMP-1-1607 bp polymorphism shows ethnic diversity, and that the hypothesis that this polymorphism is associated with epithelial ovarian cancer is not supported by this study in a Korean population. Moreover, this finding concurs with results obtained in white Americans and Europeans. © 2007 The Authors.
DOI
10.1111/j.1447-0756.2007.00511.x
Appears in Collections:
의과대학 > 의학과 > Journal papers
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