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Antinociceptive synergy between the cannabinoid receptor agonist WIN 55,212-2 and bupivacaine in the rat formalin test

Title
Antinociceptive synergy between the cannabinoid receptor agonist WIN 55,212-2 and bupivacaine in the rat formalin test
Authors
Kang S.Kim C.H.Lee H.Kim D.Y.Han J.I.Chung R.K.Lee G.Y.
Ewha Authors
이귀용김치효정락경한종인김동연이희승
SCOPUS Author ID
이귀용scopus; 김치효scopus; 정락경scopus; 한종인scopus; 김동연scopus; 이희승scopus
Issue Date
2007
Journal Title
Anesthesia and Analgesia
ISSN
0003-2999JCR Link
Citation
vol. 104, no. 3, pp. 719 - 725
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
BACKGROUND: The analgesic interaction between cannabinoids and local anesthetics has not been investigated. We sought to determine the nature of the interaction between the intrathecal cannabinoid receptor agonist (WIN 55,212-2) and bupivacaine using the formalin test. METHODS: Lumbar intrathecal catheters were implanted in male Sprague-Dawley rats. After intrathecal administration of WIN 55,212-2, bupivacaine, or their combination, 50 μL of 5% formalin was injected subcutaneously into the hindpaw. Dose-response curves were established and the respective ED50 (50% effective dose) values were determined for each agent alone. Fixed-ratio combinations of WIN 55,212-2 and bupivacaine were tested for combined antinociceptive effects in the formalin test and an isobolographic analysis was performed to characterize the pharmacologic interaction of both drugs. RESULTS: Intrathecally administered WIN 55,212-2, bupivacaine, or their combination produced a dose-dependent decrease in the number of flinches during Phase 1 and 2 of the formalin test. Isobolographic analysis revealed a synergistic interaction between intrathecal WIN 55,212-2 and bupivacaine in both phases of the formalin test. In combination, the ED50 value was significantly smaller than the theoretical additive value (P < 0.05). CONCLUSIONS: These results demonstrate that intrathecally coadministered WIN 55,212-2 and bupivacaine provide synergistic antinociceptive interaction in both phases of the formalin test. © 2007 by International Anesthesia Research Society.
DOI
10.1213/01.ane.0000255291.38637.26
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의학전문대학원 > 의학과 > Journal papers
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