Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김혜순 | * |
dc.date.accessioned | 2017-02-15T08:02:55Z | - |
dc.date.available | 2017-02-15T08:02:55Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0031-3998 | * |
dc.identifier.other | OAK-3795 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234228 | - |
dc.description.abstract | Insulin-like growth factor binding protein (IGFBP)-3 binds to IGF and modulates their actions and also possesses intrinsic activities. We investigated its effects on insulin action and found that when IGFBP-3 was added to fully differentiated 3T3-L1 adipocytes in culture, insulin-stimulated glucose transport was significantly inhibited to 60% of control in a time- and dose-dependent manner. Tumor necrosis factor (TNF)-α treatment also inhibited glucose transport to the same degree as IGFBP-3 and, in addition, increased IGFBP-3 levels 3-fold. Co-treatment with TNF-α and IGFBP-3 antisense partially prevented the inhibitory effect of TNF-α on glucose transport, indicating a role for IGFBP-3 in cytokine-induced insulin resistance. Insulin-stimulated phosphorylation of the insulin receptor was markedly decreased by IGFBP-3 treatment. IGFBP-3 treatment suppressed adiponectin expression in 3T3-L1 adipocytes. Infusion of IGFBP-3 to Sprague-Dawley rats for 3 h decreased peripheral glucose uptake by 15% compared with controls as well as inhibiting glycogen synthesis. Systemic administration of IGFBP-3 to rats for 7 d resulted in a dramatic 40% decrease in peripheral glucose utilization and glycogen synthesis. These in vitro and in vivo findings demonstrate that IGFBP-3 has potent insulin-antagonizing capability and suggest a role for IGFBP-3 in cytokine-induced insulin resistance and other mechanisms involved in the development of type-2 diabetes. © International Pediatrics Research Foundation, Inc. 2007. All Rights Reserved. | * |
dc.language | English | * |
dc.title | Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 61 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 159 | * |
dc.relation.lastpage | 164 | * |
dc.relation.journaltitle | Pediatric Research | * |
dc.identifier.doi | 10.1203/pdr.0b013e31802d8a30 | * |
dc.identifier.wosid | WOS:000243714700006 | * |
dc.identifier.scopusid | 2-s2.0-33846436784 | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Ali O. | * |
dc.author.google | Shim M. | * |
dc.author.google | Lee K.-W. | * |
dc.author.google | Vuguin P. | * |
dc.author.google | Muzumdar R. | * |
dc.author.google | Barzilai N. | * |
dc.author.google | Cohen P. | * |
dc.contributor.scopusid | 김혜순(55663596500) | * |
dc.date.modifydate | 20240415133154 | * |