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Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma

Title
Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma
Authors
Suk W.N.Jong H.L.Ji H.N.Shi N.L.Su Y.K.Sug H.L.Cheol K.P.Young M.A.Won S.P.Nam J.Y.Jung Y.L.
Ewha Authors
이시내
Issue Date
2006
Journal Title
European Journal of Gastroenterology and Hepatology
ISSN
0954-691XJCR Link
Citation
vol. 18, no. 3, pp. 239 - 247
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Nodule-in-nodule-type hepatocellular carcinoma (NIN-HCC) is a useful model to illustrate the multi-step nature of hepatocarcinogenesis. To identify large-scale molecular change in early hepatocarcinogenesis, the expression profile of NIN-HCC was compared with those from three sets of individual high-grade dysplastic nodules (HGDN) and grade 1 hepatocellular carcinomas. Methods: We compared expression profiles of inner grade 1 hepatocellular carcinoma nodules and peripheral HGDN in one case of NIN-HCC using spotted-oligonucleotide DNA microarray. The relevant outlier genes assumed to associate with early carcinogenesis in hepatocellular carcinoma were identified by comparative analysis of NIN-HCC and individual cases of HGDN and grade 1 hepatocellular carcinoma, respectively. Results: From this analysis we extracted a total of 40 genes, consisting of 28 up-regulated genes and 12 downregulated genes, and more than a two-fold change in grade 1 hepatocellular carcinoma compared with HGDN. Conclusion: We assessed the expression profiles of pre-neoplastic lesions and grade 1 hepatocellular carcinoma using oligonucleotide microarray analysis and found high stringent outlier genes that are presumably directly involved in the transition from dysplastic nodule to the early stage of hepatocellular carcinoma by utilizing NIN-HCC. © 2006 Lippincott Williams & Wilkins.
DOI
10.1097/00042737-200603000-00003
Appears in Collections:
의과대학 > 의학과 > Journal papers
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