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Serum uric acid: A risk factor and a target for treatment?

Title
Serum uric acid: A risk factor and a target for treatment?
Authors
Feig D.I.Mazzali M.Kang D.-H.Nakagawa T.Price K.Kannelis J.Johnson R.J.
Ewha Authors
강덕희
SCOPUS Author ID
강덕희scopus
Issue Date
2006
Journal Title
Journal of the American Society of Nephrology
ISSN
1046-6673JCR Link
Citation
vol. 17, no. SUPPL. 2, pp. S69 - S73
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Serum uric acid was first noted to be associated with increased BP by Frederick Mohamed in the 1870s. Although the link was rediscovered periodically over the years, it generally was dismissed as a surrogate marker for decreased renal function that led to increased uric acid and increased risk for hypertension and cardiovascular (CV) disease. Recently, however, several lines of evidence suggest that increased serum uric acid may be a significant modifiable risk factor. Increased serum uric acid is associated with increased risk for future hypertension in several large longitudinal clinical trials as well as an independent risk factor for poor CV prognosis. Animal model experiments demonstrate that increased serum uric acid causes increased BP that initially is reversible but becomes irreversible, salt sensitive, and uric acid independent over time. The mechanisms include the direct action of uric acid on smooth muscle and vascular endothelial cells. Finally, in adolescents with new-onset essential hypertension, the prevalence of elevated serum uric acid is >90%, and preliminary clinical trial evidence suggests that agents that lower serum uric acid may lower BP in this select population. Although the investigations are still preliminary, serum uric acid represents a possible new and intriguing target for the reduction of morbidity and mortality associated with hypertension and CV disease. Copyright © 2006 by the American Society of Nephrology.
DOI
10.1681/ASN.2005121331
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의학전문대학원 > 의학과 > Journal papers
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