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Synthesis of 5-ethyl-2-{5-[4-(2-hydroxyethyl)piperazin-1-ylsulfonyl]-2-n- propoxyphenyl}-7-n-propyl-3,5-dihydro-4H-pyrrolo[3,2-d]-[2-14C] pyrimidin-4-one · 2 HCl (14C-SK3530 · 2 HCl)

Title
Synthesis of 5-ethyl-2-{5-[4-(2-hydroxyethyl)piperazin-1-ylsulfonyl]-2-n- propoxyphenyl}-7-n-propyl-3,5-dihydro-4H-pyrrolo[3,2-d]-[2-14C] pyrimidin-4-one · 2 HCl (14C-SK3530 · 2 HCl)
Authors
Shin H.-I.Lee J.Kim D.-K.
Ewha Authors
김대기
SCOPUS Author ID
김대기scopus
Issue Date
2006
Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
ISSN
0362-4803JCR Link
Citation
vol. 49, no. 13, pp. 1141 - 1149
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new 14C-labelled PDE5 inhibitor, 5-ethyl-2-{5-[4-(2- hydroxyethyl)piperazin-1-ylsulfonyl]-2-n-propoxyphenyl}-7-n-propyl-3, 5-dihydro-4H-pyrrolo[3,2-d]-[2-14C]pyrimidin-4-one · 2 HCl (14C-SK3530 · 2 HCl) (1-2 HCl) was synthesized through a straightforward six-step sequence from the readily available [ 14C-carbonyl]methyl salicylate (2). The overall radiochemical yield of the 1 · 2 HCl from 2 was 10.5%, and its radiochemical purity was 98.8%. Copyright © 2006 John Wiley & Sons, Ltd.
DOI
10.1002/jlcr.1116
Appears in Collections:
약학대학 > 약학과 > Journal papers
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