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Protein kinase CK2 is inhibited by human nucleolar phosphoprotein p140 in an inositol hexakisphosphate-dependent manner

Title
Protein kinase CK2 is inhibited by human nucleolar phosphoprotein p140 in an inositol hexakisphosphate-dependent manner
Authors
Kim Y.-K.Kong J.L.Jeon H.Yeon G.Y.
Ewha Authors
이공주
SCOPUS Author ID
이공주scopus
Issue Date
2006
Journal Title
Journal of Biological Chemistry
ISSN
0021-9258JCR Link
Citation
vol. 281, no. 48, pp. 36752 - 36757
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Protein kinase CK2 is a ubiquitous protein kinase that can phosphorylate various proteins involved in central cellular processes, such as signal transduction, cell division, and proliferation. We have shown that the human nucleolar phosphoprotein p140 (hNopp140) is able to regulate the catalytic activity of CK2. Unphosphorylated hNopp140 and phospho-hNopp140 bind to the regulatory and catalytic subunits of CK2, respectively, and the interaction between hNopp140 and CK2 was prevented by inositol hexakisphosphate (InsP 6). Phosphorylation of α-casein, genimin, or human phosphatidylcholine transfer protein-like protein by CK2 was inhibited by hNopp140, and InsP6 recovered the suppressed activity of CK2 by hNopp140. These observations indicated that hNopp140 serves as a negative regulator of CK2 and that InsP6 stimulates the activity of CK2 by blocking the interaction between hNopp140 and CK2. © 2006 by The American Society for Biochemistry and Molecular Biology, Inc.
DOI
10.1074/jbc.M604785200
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약학대학 > 약학과 > Journal papers
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