Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 최진호 | - |
dc.contributor.author | 김상태 | - |
dc.date.accessioned | 2017-02-15T08:02:41Z | - |
dc.date.available | 2017-02-15T08:02:41Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.other | OAK-3655 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234156 | - |
dc.description.abstract | We present the mechanism for the cellular uptake of layered double hydroxide (LDH) nanoparticles that are internalized into MNNG/HOS cells principally via clathrin-mediated endocytosis. The intracellular LDHs are highly colocalized with not only typical endocytic proteins, such as clathrin heavy chain, dynamin, and eps15, but also transferrin, a marker of the clathrin-mediated process, suggesting their specific internalization pathway. LDHs loaded with an anticancer drug (MTX-LDH) were also prepared to confirm the efficacy of LDHs as drug delivery systems. The cellular uptake of MTX was higher in MTX-LDH-treated cells than in MTX-treated cells, giving a lower IC 50 value for MTX-LDH than for MTX only. The inhibition of the cell cycle was greater for MTX-LDH than for MTX only. This result clearly shows that the internalization of LDH nanoparticles via clathrin-mediated endocytosis may allow the efficient delivery of MTX-LDH in cells and thus enhance drug efficacy. © 2006 American Chemical Society. | - |
dc.language | English | - |
dc.title | Cellular uptake mechanism of an inorganic nanovehicle and its drug conjugates: Enhanced efficacy due to clathrin-mediated endocytosis | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 17 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1411 | - |
dc.relation.lastpage | 1417 | - |
dc.relation.journaltitle | Bioconjugate Chemistry | - |
dc.identifier.doi | 10.1021/bc0601323 | - |
dc.identifier.wosid | WOS:000242020900007 | - |
dc.identifier.scopusid | 2-s2.0-33845188629 | - |
dc.author.google | Oh J.-M. | - |
dc.author.google | Choi S.-J. | - |
dc.author.google | Kim S.-T. | - |
dc.author.google | Choy J.-H. | - |
dc.contributor.scopusid | 최진호(8044393000) | - |
dc.date.modifydate | 20200911081002 | - |