Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정낙신 | - |
dc.date.accessioned | 2017-02-15T08:02:39Z | - |
dc.date.available | 2017-02-15T08:02:39Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1477-0520 | - |
dc.identifier.other | OAK-3639 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234148 | - |
dc.description.abstract | l-N-MCd4T (1) has been synthesized as a potent anti-HIV agent starting from (R)-epichlorohydrin using tandem alkylation, chemoselective reduction of ester in the presence of lactone functional group, RCM reaction and Mitsunobu reaction as key steps and was found to be a very potent anti-HIV-1 (EC50 = 6.76 g mL-1) agent without cytotoxicity up to 100 g mL-1, indicating that the anti-HIV-1 activity found is similar to that of ddI (EC 50 = 4.95 g mL-1), which is used clinically for the treatment of AIDS patients. © The Royal Society of Chemistry 2006. | - |
dc.language | English | - |
dc.title | Synthesis of novel l-N-MCd4T as a potent anti-HIV agent | - |
dc.type | Article | - |
dc.relation.issue | 22 | - |
dc.relation.volume | 4 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 4065 | - |
dc.relation.lastpage | 4067 | - |
dc.relation.journaltitle | Organic and Biomolecular Chemistry | - |
dc.identifier.doi | 10.1039/b612537a | - |
dc.identifier.wosid | WOS:000241720500005 | - |
dc.identifier.scopusid | 2-s2.0-33750503810 | - |
dc.author.google | Park A.-Y. | - |
dc.author.google | Moon H.R. | - |
dc.author.google | Kim K.R. | - |
dc.author.google | Chun M.W. | - |
dc.author.google | Jeong L.S. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.date.modifydate | 20211210153610 | - |