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dc.contributor.author정낙신-
dc.date.accessioned2017-02-15T08:02:39Z-
dc.date.available2017-02-15T08:02:39Z-
dc.date.issued2006-
dc.identifier.issn1477-0520-
dc.identifier.otherOAK-3639-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/234148-
dc.description.abstractl-N-MCd4T (1) has been synthesized as a potent anti-HIV agent starting from (R)-epichlorohydrin using tandem alkylation, chemoselective reduction of ester in the presence of lactone functional group, RCM reaction and Mitsunobu reaction as key steps and was found to be a very potent anti-HIV-1 (EC50 = 6.76 g mL-1) agent without cytotoxicity up to 100 g mL-1, indicating that the anti-HIV-1 activity found is similar to that of ddI (EC 50 = 4.95 g mL-1), which is used clinically for the treatment of AIDS patients. © The Royal Society of Chemistry 2006.-
dc.languageEnglish-
dc.titleSynthesis of novel l-N-MCd4T as a potent anti-HIV agent-
dc.typeArticle-
dc.relation.issue22-
dc.relation.volume4-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage4065-
dc.relation.lastpage4067-
dc.relation.journaltitleOrganic and Biomolecular Chemistry-
dc.identifier.doi10.1039/b612537a-
dc.identifier.wosidWOS:000241720500005-
dc.identifier.scopusid2-s2.0-33750503810-
dc.author.googlePark A.-Y.-
dc.author.googleMoon H.R.-
dc.author.googleKim K.R.-
dc.author.googleChun M.W.-
dc.author.googleJeong L.S.-
dc.contributor.scopusid정낙신(16028528200)-
dc.date.modifydate20211210153610-
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약학대학 > 약학과 > Journal papers
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