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Synthesis of novel l-N-MCd4T as a potent anti-HIV agent

Title
Synthesis of novel l-N-MCd4T as a potent anti-HIV agent
Authors
Park A.-Y.Moon H.R.Kim K.R.Chun M.W.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2006
Journal Title
Organic and Biomolecular Chemistry
ISSN
1477-0520JCR Link
Citation
vol. 4, no. 22, pp. 4065 - 4067
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
l-N-MCd4T (1) has been synthesized as a potent anti-HIV agent starting from (R)-epichlorohydrin using tandem alkylation, chemoselective reduction of ester in the presence of lactone functional group, RCM reaction and Mitsunobu reaction as key steps and was found to be a very potent anti-HIV-1 (EC50 = 6.76 g mL-1) agent without cytotoxicity up to 100 g mL-1, indicating that the anti-HIV-1 activity found is similar to that of ddI (EC 50 = 4.95 g mL-1), which is used clinically for the treatment of AIDS patients. © The Royal Society of Chemistry 2006.
DOI
10.1039/b612537a
Appears in Collections:
약학대학 > 약학과 > Journal papers
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