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Bimodal actions of reactive oxygen species in the differentiation and bone-resorbing functions of osteoclasts

Title
Bimodal actions of reactive oxygen species in the differentiation and bone-resorbing functions of osteoclasts
Authors
Kim H.Kim I.Y.Lee S.Y.Jeong D.
Ewha Authors
이수영
SCOPUS Author ID
이수영scopus
Issue Date
2006
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
vol. 580, no. 24, pp. 5661 - 5665
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In order to demonstrate that cellular redox status undergoes decreased reduction during osteoclast differentiation and further decreased reduction during osteoclastic bone resorption, we analyzed γ-glutamylcysteinyl synthetase activity, a glutathione synthesis rate-limiting enzyme, and total glutathione and thiol groups. Moderate and severe redox shifts towards a more oxidizing environment induced gradual increases and decreases in osteoclastogenesis. Moreover, while severe glutathione depletion inhibited bone resorption, moderate glutathione repletion enhanced bone resorption. In summary, our observations suggest that there is a threshold for redox status, representing biphasic patterns in osteoclast differentiation and function. © 2006 Federation of European Biochemical Societies.
DOI
10.1016/j.febslet.2006.09.015
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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