Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2017-02-15T08:02:29Z | - |
dc.date.available | 2017-02-15T08:02:29Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.other | OAK-3523 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/234099 | - |
dc.description.abstract | Cyclooxygenase-2 (COX-2) expression is induced in the neurons of the pathologic brain and elevated COX-2 expressions can lead to neuronal death. Here, we report that COX-2 induction in cortical neurons induced by LPS pretreatment for more than 12 h increased the neurotoxic effects of low doses of Fe2+ by more than 2.5-fold. Moreover, the neurotoxicity induced by 30 μM Fe2+ in LPS-pretreated cells exceeded that induced by 100 μM Fe2+ in LPS-untreated cells. LPS pretreatment also similarly aggravated the neurotoxic effects of low doses of H2O2, Zn2+, and sodium nitroprusside. This LPS-induced Fe2+-toxicity enhancement was blocked by trolox, vitamin C, the SOD mimetic MnTBAP, and by the COX-2-specific inhibitor NS398, but not by inhibitors of xanthine oxidase, NADPH oxidase, NOS, and monoamine oxidase. Cortical neurons with enhanced COX-2 expression showed superoxide generation, GSH depletion, and lipid peroxidation in response to low doses of Fe2+, and all of these changes were repressed by MnTBAP or NS398. Consistent with this pharmacological data, cortical neurons prepared from COX-2 knockout mice showed marked reductions in LPS-induced Fe2+-toxicity enhancement and superoxide generation. These results suggest that COX-2 functions as a cellular factor which induces superoxide-mediated cell death in primary cortical neurons. © 2006 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | Cyclooxygenase-2-dependent neuronal death proceeds via superoxide anion generation | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 41 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 960 | - |
dc.relation.lastpage | 972 | - |
dc.relation.journaltitle | Free Radical Biology and Medicine | - |
dc.identifier.doi | 10.1016/j.freeradbiomed.2006.06.001 | - |
dc.identifier.wosid | WOS:000240322100015 | - |
dc.identifier.scopusid | 2-s2.0-33747348720 | - |
dc.author.google | Im J.-Y. | - |
dc.author.google | Kim D. | - |
dc.author.google | Paik S.-G. | - |
dc.author.google | Han P.-L. | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |