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dc.contributor.author한평림-
dc.date.accessioned2017-02-15T08:02:29Z-
dc.date.available2017-02-15T08:02:29Z-
dc.date.issued2006-
dc.identifier.issn0891-5849-
dc.identifier.otherOAK-3523-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/234099-
dc.description.abstractCyclooxygenase-2 (COX-2) expression is induced in the neurons of the pathologic brain and elevated COX-2 expressions can lead to neuronal death. Here, we report that COX-2 induction in cortical neurons induced by LPS pretreatment for more than 12 h increased the neurotoxic effects of low doses of Fe2+ by more than 2.5-fold. Moreover, the neurotoxicity induced by 30 μM Fe2+ in LPS-pretreated cells exceeded that induced by 100 μM Fe2+ in LPS-untreated cells. LPS pretreatment also similarly aggravated the neurotoxic effects of low doses of H2O2, Zn2+, and sodium nitroprusside. This LPS-induced Fe2+-toxicity enhancement was blocked by trolox, vitamin C, the SOD mimetic MnTBAP, and by the COX-2-specific inhibitor NS398, but not by inhibitors of xanthine oxidase, NADPH oxidase, NOS, and monoamine oxidase. Cortical neurons with enhanced COX-2 expression showed superoxide generation, GSH depletion, and lipid peroxidation in response to low doses of Fe2+, and all of these changes were repressed by MnTBAP or NS398. Consistent with this pharmacological data, cortical neurons prepared from COX-2 knockout mice showed marked reductions in LPS-induced Fe2+-toxicity enhancement and superoxide generation. These results suggest that COX-2 functions as a cellular factor which induces superoxide-mediated cell death in primary cortical neurons. © 2006 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.titleCyclooxygenase-2-dependent neuronal death proceeds via superoxide anion generation-
dc.typeArticle-
dc.relation.issue6-
dc.relation.volume41-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage960-
dc.relation.lastpage972-
dc.relation.journaltitleFree Radical Biology and Medicine-
dc.identifier.doi10.1016/j.freeradbiomed.2006.06.001-
dc.identifier.wosidWOS:000240322100015-
dc.identifier.scopusid2-s2.0-33747348720-
dc.author.googleIm J.-Y.-
dc.author.googleKim D.-
dc.author.googlePaik S.-G.-
dc.author.googleHan P.-L.-
dc.contributor.scopusid한평림(7201947605)-
dc.date.modifydate20170601143155-
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일반대학원 > 뇌·인지과학과 > Journal papers
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