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Structure-activity relationship of neuroprotective and reactive oxygen species scavenging activities for allium organosulfur compounds

Title
Structure-activity relationship of neuroprotective and reactive oxygen species scavenging activities for allium organosulfur compounds
Authors
Kim J.-M.Hyun J.C.Kim W.-K.Chang N.Hyang S.C.
Ewha Authors
김원기장남수
SCOPUS Author ID
장남수scopus
Issue Date
2006
Journal Title
Journal of Agricultural and Food Chemistry
ISSN
0021-8561JCR Link
Citation
vol. 54, no. 18, pp. 6547 - 6553
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The neuroprotective and antioxidative activities of five organosulfur compounds with a thioallyl structure (-S-CH2CH=CH2) were characterized in terms of structure-activity relationships. Among five organosulfur compounds, only S-allyl-L-cysteine (SAC) having the alanyl group (-CH2CH-NH2-COOH) and lacking the oxo (O=) group with in between molecular properties, was effective in protecting cell death induced by both oxygen glucose deprivation and global cerebral ischemia. Conversely, lipophillic organosulfur compounds including diallyl sulfide, diallyl disulfide, and diallyl trisulfide were devoid of in vitro and in vivo neuroprotective activities. Furthermore, a significant correlation was only found between the in vivo neuroprotective activity and the OH- scavenging activity (γ = 0.55 and p = 0.032) among reactive oxygen species scavenging activities. These results indicate that the presence of the alanyl group and the absence of the oxo group are essential for the manifestation of neuroprotective activity against ischemic insults and scavenging of OH radical, with SAC surfacing as a potent neuroprotectant. © 2006 American Chemical Society.
DOI
10.1021/jf060412c
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자연과학대학 > 화학·나노과학전공 > Journal papers
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