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A comparative histologic analysis of tissue-engineered bone using platelet-rich plasma and platelet-enriched fibrin glue

Title
A comparative histologic analysis of tissue-engineered bone using platelet-rich plasma and platelet-enriched fibrin glue
Authors
Zhu S.-J.Choi B.-H.Jung J.-H.Lee S.-H.Huh J.-Y.You T.-M.Lee H.-J.Li J.
Ewha Authors
이승호
Issue Date
2006
Journal Title
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
ISSN
1079-2104JCR Link
Citation
vol. 102, no. 2, pp. 175 - 179
Indexed
SCOPUS WOS scopus
Abstract
Objective: The aim of this study was to compare the effects of platelet-rich plasma (PRP) and platelet-enriched fibrin glue on bone formation in bone tissue engineering. Study design: PRP was mixed with bone marrow mesenchymal stem cells and bone morphogenetic protein-2 (BMP-2), and the composites were injected into the subcutaneous space on the dorsum of nude mice. On the contralateral side of the dorsum, platelet-enriched fibrin glue/bone marrow mesenchymal stem cells/BMP-2 composites were injected. Bone formation was evaluated after 12 weeks. Results: The volumes of subcutaneous nodules formed in nude mice were 55 ± 18 μL at the PRP/bone marrow mesenchymal stem cells/BMP-2 sites and 135 ± 27 μL at the platelet-enriched fibrin glue/bone marrow mesenchymal stem cells/BMP-2 sites. Histomorphometric analysis demonstrated that the nodules contained 14.9 ± 4.1% newly formed bone when using PRP and 19.8 ± 3.6% newly formed bone when using platelet-enriched fibrin glue. Conclusion: The results indicated that the osteogenic characteristics of platelet-enriched fibrin glue are superior to PRP in bone tissue engineering. © 2006 Mosby, Inc. All rights reserved.
DOI
10.1016/j.tripleo.2005.08.034
Appears in Collections:
의과대학 > 의학과 > Journal papers
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