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An essential complementary role of NF-κB pathway to microbicidal oxidants in Drosophila gut immunity

Title
An essential complementary role of NF-κB pathway to microbicidal oxidants in Drosophila gut immunity
Authors
Ryu J.-H.Ha E.-M.Oh C.-T.Seol J.-H.Brey P.T.Jin I.Lee D.G.Kim J.Lee D.Lee W.-J.
Ewha Authors
이원재김재상이대기
SCOPUS Author ID
김재상scopus; 이대기scopus
Issue Date
2006
Journal Title
EMBO Journal
ISSN
0261-4189JCR Link
Citation
vol. 25, no. 15, pp. 3693 - 3701
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In the Drosophila gut, reactive oxygen species (ROS)-dependent immunity is critical to host survival. This is in contrast to the NF-κB pathway whose physiological function in the microbe-laden epithelia has yet to be convincingly demonstrated despite playing a critical role during systemic infections. We used a novel in vivo approach to reveal the physiological role of gut NF-κB/antimicrobial peptide (AMP) system, which has been 'masked' in the presence of the dominant intestinal ROS-dependent immunity. When fed with ROS-resistant microbes, NF-κB pathway mutant flies, but not wild-type flies, become highly susceptible to gut infection. This high lethality can be significantly reduced by either re-introducing Relish expression to Relish mutants or by constitutively expressing a single AMP to the NF-κB pathway mutants in the intestine. These results imply that the local 'NF-κB/AMP' system acts as an essential 'fail-safe' system, complementary to the ROS-dependent gut immunity, during gut infection with ROS-resistant pathogens. This system provides the Drosophila gut immunity the versatility necessary to manage sporadic invasion of virulent pathogens that somehow counteract or evade the ROS-dependent immunity. ©2006 European Molecular Biology Organization.
DOI
10.1038/sj.emboj.7601233
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일반대학원 > 바이오융합과학과 > Journal papers
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