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Chloroform extract of deer antler inhibits osteoclast differentiation and bone resorption

Title
Chloroform extract of deer antler inhibits osteoclast differentiation and bone resorption
Authors
Li Y.-J.Kim T.-H.Kwak H.B.Lee Z.H.Lee S.-Y.Jhon G.-J.
Ewha Authors
전길자이수영
SCOPUS Author ID
전길자scopus; 이수영scopus
Issue Date
2007
Journal Title
Journal of Ethnopharmacology
ISSN
0378-8741JCR Link
Citation
vol. 113, no. 2, pp. 191 - 198
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
It has been reported that deer antler extract has anti-bone resorptive activity in vivo. However, little is known about the cellular and molecular mechanism of this effect. In this study, we investigated the effects of deer antler extracts on osteoclast differentiation and bone-resorption in vitro. Chloroform extract (CE-C) of deer antler inhibited osteoclast differentiation in mouse bone marrow cultures stimulated by receptor activator of NF-κB ligand (RANKL) and macrophage-colony stimulating factor (M-CSF). CE-C suppressed the activation of extracellular signal-regulated kinase (ERK), protein kinase B (PKB/Akt) and inhibitor of kappa B (I-κB) by RANKL in osteoclast precursor cells. It also inhibited the bone resorptive activity of differentiated osteoclasts that was accompanied by disruption of actin rings and induction of the apoptosis. These results demonstrate deer antler extract may be a useful remedy for the treatment of bone-resorption diseases such as osteoporosis. © 2007 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.jep.2007.04.020
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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