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Single nucleotide polymorphisms and haplotypes of the genes encoding the CYP1B1 in Korean women: No association with advanced endometriosis

Title
Single nucleotide polymorphisms and haplotypes of the genes encoding the CYP1B1 in Korean women: No association with advanced endometriosis
Authors
Cho Y.J.Hur S.E.Lee J.Y.Song I.O.Moon H.-S.Koong M.K.Chung H.W.
Ewha Authors
정혜원문혜성
SCOPUS Author ID
정혜원scopus; 문혜성scopus
Issue Date
2007
Journal Title
Journal of Assisted Reproduction and Genetics
ISSN
1058-0468JCR Link
Citation
vol. 24, no. 7, pp. 271 - 277
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Objective: To investigate whether single nucleotide polymorphisms and its haplotypes of gene encoding CYP1B1 are associated with the risk of advanced endometriosis in Korean women. Methods: We investigated 221 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 188 control group women who were surgically proven to have no endometriosis. The genetic distribution of four different CYP1B1 polymorphisms at Ala119Ser, Leu432Val, Asp449(C>T), Asn453Ser were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism of PCR products. Haplotype analysis was also performed. Results: We found no overall association between each individual CYP1B1 genotype or haplotype and the risk of endometriosis. Also, the odds ratio of each haplotypes of CYP1B1 showed no association with the risk of endometriosis. Conclusions: These results suggest that CYP1B1 genetic polymorphism may not be associated with development of advanced endometriosis in Korean women. © 2007 Springer Science+Business Media, LLC.
DOI
10.1007/s10815-007-9122-0
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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