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Identification of Nyasol and structurally related compounds as the active principles from Anemarrhena asphodeloides against respiratory syncytial virus (RSV)

Title
Identification of Nyasol and structurally related compounds as the active principles from Anemarrhena asphodeloides against respiratory syncytial virus (RSV)
Authors
Bae G.Yu J.-R.Lee J.Chang J.Seo E.-K.
Ewha Authors
서은경장준
SCOPUS Author ID
서은경scopus; 장준scopus
Issue Date
2007
Journal Title
Chemistry and Biodiversity
ISSN
1612-1872JCR Link
Citation
vol. 4, no. 9, pp. 2231 - 2235
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Three known phenolic compounds, (-)-(R)-nyasol (=4,4′-(1Z,3R)-Penta-1,4-diene-1,3-diyldiphenol; 1), its derivative 2, and broussonin A (3) - isolated from the rhizomes of Anemarrhena asphodeloides - were for the first time identified as the active principles capable of efficient respiratory-syncytial-virus (RSV) inhibition. The IC50 values of 1-3 against the RSV-A2 strain, propagated in HEp-2 cells, were determined, their activities being higher than that of the standard antiviral drug ribavirin (IC50 = 1.15 μm). In addition, the known, but inactive, compound 'trans-N-(para-coumaroyl)tyramine' (=(2E)-3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide; 4) was isolated from this plant for the first time. © 2007 Verlag Helvetica Chimica Acta AG, Zürich.
DOI
10.1002/cbdv.200790181
Appears in Collections:
약학대학 > 약학과 > Journal papers
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