DSpace at EWHA: Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

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DC Field	Value	Language
dc.contributor.author	권영주	*
dc.date.accessioned	2017-01-18T02:01:32Z	-
dc.date.available	2017-01-18T02:01:32Z	-
dc.date.issued	2007	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-4350	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/233986	-
dc.description.abstract	11-Hydroxyindeno[1,2-c]isoquinolines 12a-c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ibutoxy analog 15l displayed potent in vitro cytotoxicity against four different tumor cell lines as well as topoisomerase 1 inhibitory activity. A FlexX docking study was performed to explain the topoisomerase 1 activity of 15l. © 2007 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex	*
dc.type	Article	*
dc.relation.issue	21	*
dc.relation.volume	17	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	5763	*
dc.relation.lastpage	5767	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2007.08.062	*
dc.identifier.wosid	WOS:000250287800006	*
dc.identifier.scopusid	2-s2.0-34548831094	*
dc.author.google	Van H.T.M.	*
dc.author.google	Le Q.M.	*
dc.author.google	Lee K.Y.	*
dc.author.google	Lee E.-S.	*
dc.author.google	Kwon Y.	*
dc.author.google	Kim T.S.	*
dc.author.google	Le T.N.	*
dc.author.google	Lee S.-H.	*
dc.author.google	Cho W.-J.	*
dc.contributor.scopusid	권영주(12446435600)	*
dc.date.modifydate	20240422124907	*