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Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

Title
Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex
Authors
Van H.T.M.Le Q.M.Lee K.Y.Lee E.-S.Kwon Y.Kim T.S.Le T.N.Lee S.-H.Cho W.-J.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2007
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 17, no. 21, pp. 5763 - 5767
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
11-Hydroxyindeno[1,2-c]isoquinolines 12a-c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ibutoxy analog 15l displayed potent in vitro cytotoxicity against four different tumor cell lines as well as topoisomerase 1 inhibitory activity. A FlexX docking study was performed to explain the topoisomerase 1 activity of 15l. © 2007 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2007.08.062
Appears in Collections:
약학대학 > 약학과 > Journal papers
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