View : 560 Download: 0
Cellular toxicity of inorganic hydroxide nanoparticles
- Title
- Cellular toxicity of inorganic hydroxide nanoparticles
- Authors
- Choi S.-J.; Oh J.-M.; Park T.; Choy J.-H.
- Ewha Authors
- 최진호
- SCOPUS Author ID
- 최진호
- Issue Date
- 2007
- Journal Title
- Journal of Nanoscience and Nanotechnology
- ISSN
- 1533-4880
- Citation
- Journal of Nanoscience and Nanotechnology vol. 7, no. 11, pp. 4017 - 4020
- Indexed
- SCIE; SCOPUS
- Document Type
- Conference Paper
- Abstract
- Layered double hydroxides (LDHs), anionic clays, have attracted increasing interest as nanovehicles for delivering genes, drugs, and bio-active molecules into cells. However, no attempts have been made to evaluate the potential undesirable effects of LDH nanoparticles. The cytotoxicity of LDHs with different chemical compositions (ZnAI- and MgAI-LDH) was systematically evaluated in various cell types, such as human normal cells, carcinoma cells, and red blood cells, by measuring cell viability, cell proliferation, membrane damage, and hemolytic effect. No significant cytotoxic effects could be seen in both cases, but ZnAI-LDH was determined to be slightly more toxic than MgAI-LDH in terms of membrane damage and hemolysis induction. It is, therefore, expected that LDHs could be promising candidates for novel inorganic drug delivery carriers. Copyright © 2007 American Scientific Publishers All rights reserved.
- DOI
- 10.1166/jnn.2007.085
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML