View : 47 Download: 0

Cellular toxicity of inorganic hydroxide nanoparticles

Title
Cellular toxicity of inorganic hydroxide nanoparticles
Authors
Choi S.-J.Oh J.-M.Park T.Choy J.-H.
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2007
Journal Title
Journal of Nanoscience and Nanotechnology
ISSN
1533-4880JCR Link
Citation
vol. 7, no. 11, pp. 4017 - 4020
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Layered double hydroxides (LDHs), anionic clays, have attracted increasing interest as nanovehicles for delivering genes, drugs, and bio-active molecules into cells. However, no attempts have been made to evaluate the potential undesirable effects of LDH nanoparticles. The cytotoxicity of LDHs with different chemical compositions (ZnAI- and MgAI-LDH) was systematically evaluated in various cell types, such as human normal cells, carcinoma cells, and red blood cells, by measuring cell viability, cell proliferation, membrane damage, and hemolytic effect. No significant cytotoxic effects could be seen in both cases, but ZnAI-LDH was determined to be slightly more toxic than MgAI-LDH in terms of membrane damage and hemolysis induction. It is, therefore, expected that LDHs could be promising candidates for novel inorganic drug delivery carriers. Copyright © 2007 American Scientific Publishers All rights reserved.
DOI
10.1166/jnn.2007.085
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE