View : 18 Download: 0

Phenotypic changes induced by IL-12 priming regulate effector and memory CD8 T cell differentiation

Title
Phenotypic changes induced by IL-12 priming regulate effector and memory CD8 T cell differentiation
Authors
Lee J.-B.Lee K.-A.Chang J.
Ewha Authors
장준
SCOPUS Author ID
장준scopus
Issue Date
2007
Journal Title
International Immunology
ISSN
0953-8178JCR Link
Citation
vol. 19, no. 9, pp. 1039 - 1048
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In addition to TCR and co-stimulatory signals, inflammatory cytokines such as IL-12 provide important signals for differentiation and survival of activated CD8 T cells. In the present study, to investigate the mechanisms by which IL-12 priming contributes to activation and enhanced survival of CD8 T cells, we searched the differentially regulated genes and markers by IL-12 during antigenic stimulation. Here, we show that IL-12 priming results in the increased subpopulation of CD127hi cells, which differentiates into long-lived memory cells. We also found that IL-12 priming induces IL-10 expression from activated CD8 T cells, which is distinct from CD127 up-regulation. Direct IL-10 priming of CD8 T cells results in the significant increase of effector and memory CD8 T cell population after adoptive transfer, and this priming effect is closely associated with less susceptibility to apoptosis. Although IL-10 is known as a cytokine with anti-inflammatory and immunosuppressive properties, our results have shown that IL-10 has a direct and positive effect on the survival of CD8 T cells. Together, we suggest that IL-10-dependent and independent effects of IL-12 play important roles in regulating differentiation and survival of activated CD8 T cells into effector and memory cells. © The Author 2007. Published by Oxford University Press on behalf of The Japanese Society for Immunology. All rights reserved.
DOI
10.1093/intimm/dxm072
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE