Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박시훈 | - |
dc.date.accessioned | 2017-01-18T02:01:26Z | - |
dc.date.available | 2017-01-18T02:01:26Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0149-2918 | - |
dc.identifier.other | OAK-4479 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233925 | - |
dc.description.abstract | Background: Although previous studies have examined the efficacy of pitavastatin, its tolerability and effects on lipid concentrations have not been compared with those of atorvastatin in a multicenter, randomized study. Objective: This trial compared the efficacy and tolerability of pitavastatin and atorvastatin in hypercholesterolemic Korean adults. Methods: This 8-week, multicenter, randomized, open-label, dose-titration study was conducted at 18 clinical centers in Korea between May 2005 and February 2006. After a 4-week dietary lead-in period, patients with hypercholesterolemia were randomized to receive either pitavastatin 2 mg/d or atorvastatin 10 mg/d. Patients who had not reached the low-density lipoprotein cholesterol (LDL-C) goal by week 4 received a double dose of the assigned medication for an additional 4 weeks. Efficacy was evaluated in terms of achievement of the National Cholesterol Education Program Adult Treatment Panel III LDL-C goals and changes from baseline in other lipids and high-sensitivity C-reactive protein (hs-CRP). The tolerability profile was assessed by physical and electro-cardiographic examinations, laboratory tests, and recording adverse reactions at all visits. Results: A total of 268 patients were randomized to treatment, and 222 (82.8%) completed the study (149 women, 73 men; mean age, 59 years; mean weight, 63.5 kg). At the end of the study, there was no significant difference between the pitavastatin and atorvastatin groups in the proportion of patients achieving the LDL-C goal (92.7% [102/110] vs 92.0% [103/112], respectively). In addition, there were no significant differences between groups in terms of the percent changes from baseline in LDL-C, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), or hs-CRP. Twenty-six of 136 patients (19.1%) taking pitavastatin reported 35 treatment-emergent adverse reactions; 33 of 132 patients (25.0%) taking atorvastatin reported 39 treatment-emergent adverse reactions. Elevations in creatine kinase were observed in 6 patients (4.4%) in the pitavastatin group and 7 patients (5.3%) in the atorvastatin group. There were no serious adverse drug reactions in either group. Conclusions: In these adult Korean patients with hypercholesterolemia, pitavastatin and atorvastatin did not differ significantly in terms of the proportions of patients achieving the LDL-C goal; reductions in LDL-C, total cholesterol, and triglycerides; or increases in HDL-C. Both drugs were well tolerated. © 2007 Excerpta Medica, Inc. | - |
dc.language | English | - |
dc.title | Comparison of the efficacy and tolerability of pitavastatin and atorvastatin: An 8-week, multicenter, randomized, open-label, dose-titration study in korean patients with hypercholesterolemia | - |
dc.type | Article | - |
dc.relation.issue | 11 | - |
dc.relation.volume | 29 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2365 | - |
dc.relation.lastpage | 2373 | - |
dc.relation.journaltitle | Clinical Therapeutics | - |
dc.identifier.doi | 10.1016/j.clinthera.2007.11.002 | - |
dc.identifier.wosid | WOS:000251697800007 | - |
dc.identifier.scopusid | 2-s2.0-37349123865 | - |
dc.author.google | Hak Lee S. | - |
dc.author.google | Chung N. | - |
dc.author.google | Kwan J. | - |
dc.author.google | Kim D.-I. | - |
dc.author.google | Ho Kim W. | - |
dc.author.google | Jeong Kim C. | - |
dc.author.google | Seung Kim H. | - |
dc.author.google | Hoon Park S. | - |
dc.author.google | Seog Seo H. | - |
dc.author.google | Gu Shin D. | - |
dc.author.google | Woo Shin Y. | - |
dc.author.google | Shim W.-J. | - |
dc.author.google | Ahn T.H. | - |
dc.author.google | Ho Yun K. | - |
dc.author.google | Yoon M.-H. | - |
dc.author.google | Cha K.-S. | - |
dc.author.google | Choi S.-W. | - |
dc.author.google | Wook Han S. | - |
dc.author.google | Su Hyon M. | - |
dc.contributor.scopusid | 박시훈(9737584900;57191750840) | - |
dc.date.modifydate | 20221123115020 | - |