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약학대학
약학과
Journal papers
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Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines
Title
Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines
Authors
Jeong L.S.
;
Zhao L.X.
;
Choi W.J.
;
Pal S.
;
Park Y.H.
;
Lee S.K.
;
Chun M.W.
;
Lee Y.B.
;
Ahn C.H.
;
Moon H.R.
Ewha Authors
정낙신
;
이상국
SCOPUS Author ID
정낙신
; 이상국
Issue Date
2007
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770
Citation
Nucleosides, Nucleotides and Nucleic Acids vol. 26, no. 41432, pp. 713 - 716
Indexed
SCIE; SCOPUS
Document Type
Conference Paper
Abstract
Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from D-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines. Copyright © Taylor & Francis Group, LLC.
DOI
10.1080/15257770701490852
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