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Synthesis of N6-Substituted 3′-ureidoadenosine derivatives as highly potent agonists at the mutant A3 adenosine receptor

Title
Synthesis of N6-Substituted 3′-ureidoadenosine derivatives as highly potent agonists at the mutant A3 adenosine receptor
Authors
Jeong L.S.Choe S.A.Kim A.Y.Kim H.O.Gao Z.-G.Jacobson K.A.Chun M.W.Moon H.R.
Ewha Authors
정낙신
Issue Date
2007
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770JCR Link
Citation
vol. 26, no. 41432, pp. 717 - 719
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Several N6-substituted 3′-ureidoadenosine derivatives were efficiently synthesized starting from D-glucose for the development of H272E mutant A3 adenosine receptor (AR) agonists. Among compounds tested, 3′-ureido-N6-(3-iodobenzyl)adenosine (2c) exhibited the highest binding affinity (Ki = 0.22 μ M) at the H272E mutant A3 AR without binding to the natural A3AR. Copyright © Taylor & Francis Group, LLC.
DOI
10.1080/15257770701493161
Appears in Collections:
약학대학 > 약학과 > Journal papers
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