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Design, enantiopure synthesis, and biological evaluation of novel ISO-D-2′,3′-dideoxy-3′-fluorothianucleoside derivatives as a bioisostere of lamivudine

Title
Design, enantiopure synthesis, and biological evaluation of novel ISO-D-2′,3′-dideoxy-3′-fluorothianucleoside derivatives as a bioisostere of lamivudine
Authors
Kim K.R.Park A.-Y.Moon H.R.Chun M.W.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2007
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770JCR Link
Citation
vol. 26, no. 41495, pp. 911 - 915
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Novel iso D-2′,3′-dideoxythianucleoside derivatives 1-3 were designed and asymmetrically synthesized to search for new anti-HIV agents. Final compounds 1-3 were evaluated against a variety of viruses including HIV-1 and 2. Only cytosine analog 3 showed a potent anti-VSV activity (EC50 = 9.43 μg/mL). This result implies that iso 2′,3′-dideoxy sugar templates might play a role of a sugar surrogate of nucleosides for the development of anti-RNA virus agent. Copyright © Taylor & Francis Group, LLC.
DOI
10.1080/15257770701506426
Appears in Collections:
약학대학 > 약학과 > Journal papers
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