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Motor cortical excitability in patients with poststroke epilepsy

Title
Motor cortical excitability in patients with poststroke epilepsy
Authors
Kim J.H.Lee H.W.Cohen L.G.Park K.-D.Choi K.-G.
Ewha Authors
최경규박기덕이향운
SCOPUS Author ID
최경규scopus; 박기덕scopus; 이향운scopus
Issue Date
2008
Journal Title
Epilepsia
ISSN
0013-9580JCR Link
Citation
vol. 49, no. 1, pp. 117 - 124
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Purpose: To gain insight into the mechanisms underlying poststroke epilepsy (PSE), we evaluated motor cortical function in chronic stroke patients with (N = 18) and without (N = 18) PSE. Methods: We measured resting motor threshold (RMT), motor evoked potential (MEP) amplitudes, cortical silent period (CSP), intracortical inhibition (ICI), influenced by GABAergic neurotransmission, and intracortical facilitation (ICF), influenced by glutamatergic activity, to transcranial magnetic stimulation. Results: We found (1) larger MEP amplitudes and ICF, in the affected than unaffected hemispheres of patients in the PSE group but not in patients without epilepsy, and (2) comparably higher RMT and longer CSP in the absence of differences in ICI, H-reflexes or F-waves in the affected and unaffected hemispheres of both PSE and non-PSE patients. Conclusions: Enhanced cortical excitability in the affected hemisphere, possibly related to increased glutamatergic activity, could be one of the mechanisms contributing to the development of poststroke epilepsy. © 2008 International League Against Epilepsy.
DOI
10.1111/j.1528-1167.2007.01231.x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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