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3D printed polyurethane prosthesis for partial tracheal reconstruction: A pilot animal study

Title
3D printed polyurethane prosthesis for partial tracheal reconstruction: A pilot animal study
Authors
Jung S.Y.Lee S.J.Kim H.Y.Park H.S.Wang Z.Kim H.J.Yoo J.J.Chung S.M.Kim H.S.
Ewha Authors
정성민김한수정수연
SCOPUS Author ID
정성민scopus; 김한수scopus; 정수연scopus
Issue Date
2016
Journal Title
Biofabrication
ISSN
1758-5082JCR Link
Citation
vol. 8, no. 4
Keywords
3D printingpatch-type prosthesispolyurethanescaffoldtracheal defect
Publisher
Institute of Physics Publishing
Indexed
SCIE; SCOPUS WOS scopus
Abstract
A ready-made, acellular patch-type prosthesis is desirable in repairing partial tracheal defects in the clinical setting. However, many of these prostheses may not show proper biological integration and biomechanical function when they are transplanted. In this study, we developed a novel 3D printed polyurethane (PU) tracheal scaffold with micro-scale architecture to allow host tissue infiltration and adequate biomechanical properties to withstand physiological tracheal condition. A half-pipe shaped PU scaffold (1.8 cm of height, 0.18 cm thickness, and 2 cm of diameter) was fabricated by 3D printing of PU 200 μm PU beam. The 3D printed tracheal scaffolds consisted of a porous inner microstructure with 200 ×200 ×200 μm3 sized pores and a non-porous outer layer. The mechanical properties of the scaffolds were 3.21 ±1.02 MPa of ultimate tensile strength, 2.81 ±0.58 MPa of Young's modulus, and 725% ±41% of elongation at break. To examine the function of the 3D printed tracheal scaffolds in vivo, the scaffolds were implanted into 1.0 ×0.7 cm2 sized anterior tracheal defect of rabbits. After implantation, bronchoscopic examinations revealed that the implanted tracheal scaffolds were patent for a 16 week-period. Histologic findings showed that re-epithelialization after 4 weeks of implantation and ciliated respiratory epithelium with ciliary beating after 8 weeks of implantation were observed at the lumen of the implanted tracheal scaffolds. The ingrowth of the connective tissue into the scaffolds was observed at 4 weeks after implantation. The biomechanical properties of the implanted tracheal scaffolds were continually maintained for 16 week-period. The results demonstrated that 3D printed tracheal scaffold could provide an alternative solution as a therapeutic treatment for partial tracheal defects. © 2016 IOP Publishing Ltd.
DOI
10.1088/1758-5090/8/4/045015
Appears in Collections:
의과대학 > 의학과 > Journal papers
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