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Binge drinking and hypertension on cardiovascular disease mortality in Korean men and women: A Kangwha cohort study

Title
Binge drinking and hypertension on cardiovascular disease mortality in Korean men and women: A Kangwha cohort study
Authors
Sull J.W.Yi S.W.Nam C.M.Choi K.Ohrr H.
Ewha Authors
최귀숙
Issue Date
2010
Journal Title
Stroke
ISSN
0039-2499JCR Link
Citation
vol. 41, no. 10, pp. 2157 - 2162
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background And Purpose-: The purpose of this study was to examine combined effects of hypertension and binge drinking on the risk of mortality from cardiovascular disease in Koreans. Methods-: This study followed a cohort of 6100 residents in Kangwha County, aged ≥55 years as of March 1985, for cardiovascular mortality for 20.8 years up to December 31, 2005. We calculated hazard ratios (HRs) for cardiovascular mortality by blood pressure and binge drinking habits using the Cox proportional hazard model. Binge drinkers and heavy binge drinkers were defined as having ≥6 drinks on 1 occasion and ≥12 drinks on 1 occasion. Results-: After adjusting for total alcohol consumption, male heavy binge drinkers with Grade 3 hypertension had a 12-fold increased risk of cardiovascular mortality (HR, 12.7; 95% CI, 3.47 to 46.5), whereas male binge drinkers with Grade 3 hypertension had a 4-fold increased risk of cardiovascular mortality (HR, 4.41; 95% CI, 1.38 to 14.1) when compared with nondrinkers with normal blood pressure. However, in considering separate effects of heavy binge drinking and hypertension on the risk of cardiovascular mortality, HRs were rather low (HR of heavy binge drinkers, 1.88, 1.10 to 3.20; HR of hypertensives, 2.00, 1.70 to 2.35) compared with nondrinkers with normal blood pressure. Conclusions-: Binge drinkers and heavy binge drinkers with Grade 3 hypertension showed a marked increase in cardiovascular mortality risk. Even after adjusting for total alcohol consumption, the former revealed 4.41 and the latter indicated 12.7 of HR for the risk of cardiovascular mortality. © 2010 American Heart Association, Inc.
DOI
10.1161/STROKEAHA.110.586347
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임상보건융합대학원 > 임상약학전공 > Theses_Master
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