Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이공주 | - |
dc.date.accessioned | 2017-01-05T02:01:25Z | - |
dc.date.available | 2017-01-05T02:01:25Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.other | OAK-1279 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233754 | - |
dc.description.abstract | Many transcription coactivators interact with nuclear receptors in a ligand- and C-terminal transactivation function (AF2)-dependent manner. These include activating signal cointegrator 2 (ASC-2), a recently isolated transcriptional coactivator molecule, which is amplified in human cancers and stimulates transactivation by nuclear receptors and numerous other transcription factors. In this report, we show that ASC-2 belongs to a steady-state complex of approximately 2 MDa (ASC-2 complex [ASCOM]) in HeLa nuclei. ASCOM contains retinoblastoma-binding protein RBQ-3, α/β-tubulins, and trithorax group proteins ALR-1, ALR-2, HALR, and ASH2. In particular, ALR-1/2 and HALR contain a highly conserved 130- to 140-amino-acid motif termed the SET domain, which was recently implicated in histone H3 lysine-specific methylation activities. Indeed, recombinant ALR-1, HALR, and immunopurified ASCOM exhibit very weak but specific H3-lysine 4 methylation activities in vitro, and transactivation by retinoic acid receptor appears to involve ligand-dependent recruitment of ASCOM and subsequent transient H3-lysine 4 methylation of the promoter region in vivo. Thus, ASCOM may represent a distinct coactivator complex of nuclear receptors. Further characterization of ASCOM will lead to a better understanding of how nuclear receptors and other transcription factors mediate transcriptional activation. | - |
dc.language | English | - |
dc.title | Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 23 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 140 | - |
dc.relation.lastpage | 149 | - |
dc.relation.journaltitle | Molecular and Cellular Biology | - |
dc.identifier.doi | 10.1128/MCB.23.1.140-149.2003 | - |
dc.identifier.wosid | WOS:000179970000013 | - |
dc.identifier.scopusid | 2-s2.0-0037216704 | - |
dc.author.google | Goo Y.-H. | - |
dc.author.google | Chang Sohn Y. | - |
dc.author.google | Kim D.-H. | - |
dc.author.google | Kim S.-W. | - |
dc.author.google | Kang M.-J. | - |
dc.author.google | Jung D.-J. | - |
dc.author.google | Kwak E. | - |
dc.author.google | Barlev N.A. | - |
dc.author.google | Berger S.L. | - |
dc.author.google | Chow V.T. | - |
dc.author.google | Roeder R.G. | - |
dc.author.google | Azorsa D.O. | - |
dc.author.google | Meltzer P.S. | - |
dc.author.google | Suh P.-G. | - |
dc.author.google | Song E.J. | - |
dc.author.google | Lee K.-J. | - |
dc.author.google | Lee Y.C. | - |
dc.author.google | Lee J.W. | - |
dc.contributor.scopusid | 이공주(7501497635;57191532162) | - |
dc.date.modifydate | 20230208115507 | - |