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Studies toward a synthesis of C3-epimauritine D: Construction of the macrocycle

Title
Studies toward a synthesis of C3-epimauritine D: Construction of the macrocycle
Authors
Kim Y.-A.Shin H.-N.Park M.-S.Cho S.-H.Han S.-Y.
Ewha Authors
한소엽
SCOPUS Author ID
한소엽scopus
Issue Date
2003
Journal Title
Tetrahedron Letters
ISSN
0040-4039JCR Link
Citation
vol. 44, no. 12, pp. 2557 - 2560
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We successfully synthesized a 14-membered cyclic enamide of C3-epimauritine D from the cis-2,3-pyrrolidinediol derivative. Treatment of the pyrrolidinediol with nitrobenzonitrile in an SNAr reaction efficiently installed the desired aryl-alkyl ether linkage on the N-heterocyclic system. Macrocyclization was successfully achieved by the use of TFFH as the peptide coupling reagent in the presence of HOAt. © 2003 Elsevier Science Ltd. All rights reserved.
DOI
10.1016/S0040-4039(03)00278-8
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자연과학대학 > 화학·나노과학전공 > Journal papers
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