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The Drosophila immune system detects bacteria through specific peptidoglycan recognition

Title
The Drosophila immune system detects bacteria through specific peptidoglycan recognition
Authors
Leulier F.Parquet C.Pili-Floury S.Ryu J.-H.Caroff M.Lee W.-J.Mengin-Lecreulx D.Lemaitre B.
Ewha Authors
이원재
Issue Date
2003
Journal Title
Nature Immunology
ISSN
1529-2908JCR Link
Citation
vol. 4, no. 5, pp. 478 - 484
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The Drosophila immune system discriminates between different classes of infectious microbes and responds with pathogen-specific defense reactions through selective activation of the Toll and the immune deficiency (Imd) signaling pathways. The Toll pathway mediates most defenses against Gram-positive bacteria and fungi, whereas the Imd pathway is required to resist infection by Gram-negative bacteria. The bacterial components recognized by these pathways remain to be defined. Here we report that Gram-negative diaminopimelic acid-type peptidoglycan is the most potent inducer of the Imd pathway and that the Toll pathway is predominantly activated by Gram-positive lysine-type peptidoglycan. Thus, the ability of Drosophila to discriminate between Gram-positive and Gram-negative bacteria relies on the recognition of specific forms of peptidoglycan.
DOI
10.1038/ni922
Appears in Collections:
일반대학원 > 바이오융합과학과 > Journal papers
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