Synthesis of 5-Azacytidine nucleosides with rigid sugar moiety as potential antitumor agents

Abstract

The bicyclic 3′-O,5′-C-methylene-linked and 2′-O,5′-C-methylene-linked 5-azacytidine derivatives were readily synthesized from 1,2;5,6-di-O-isopropylidene-D-glucose and evaluated against several cancer cell lines.