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Synthesis and biological evaluation of thymine nucleosides fused with 3′,4′-tetrahydrofuran ring

Title
Synthesis and biological evaluation of thymine nucleosides fused with 3′,4′-tetrahydrofuran ring
Authors
Kim M.J.Kim H.O.Kim H.-D.Kim J.H.Jeong L.S.Chun M.W.
Ewha Authors
정낙신
Issue Date
2003
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 13, no. 20, pp. 3499 - 3501
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The pyrimidine nucleosides fused with 3′,4′-tetrahydrofuran ring were successfully synthesized, starting from 1,2; 5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities against HIV-1, HIV-2, EMCV, Cox. B3 and VSV. Thymine analogue (5) and its corresponding 2′-deoxy analogue (6) exhibited high cytotoxicity instead of giving antiviral activities. © 2003 Elsevier Ltd. All rights reserved.
DOI
10.1016/S0960-894X(03)00730-3
Appears in Collections:
약학대학 > 약학과 > Journal papers
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