View : 338 Download: 182
The Homeobox Gene Caudal Regulates Constitutive Local Expression of Antimicrobial Peptide Genes in Drosophila Epithelia
- The Homeobox Gene Caudal Regulates Constitutive Local Expression of Antimicrobial Peptide Genes in Drosophila Epithelia
- Ryu J.-H.; Nam K.-B.; Oh C.-T.; Nam H.-J.; Kim S.-H.; Yoon J.-H.; Seong J.-K.; Yoo M.-A.; Jang I.-H.; Brey P.T.; Lee W.-J.
- Ewha Authors
- Issue Date
- Journal Title
- Molecular and Cellular Biology
- Molecular and Cellular Biology vol. 24, no. 1, pp. 172 - 185
- SCIE; SCOPUS
- Document Type
- In Drosophila melanogaster, although the NF-κB transcription factors play a pivotal role in the inducible expression of innate immune genes, such as antimicrobial peptide genes, the exact regulatory mechanism of the tissue-specific constitutive expression of these genes in barrier epithelia is largely unknown. Here, we show that the Drosophila homeobox gene product Caudal functions as the innate immune transcription modulator that is responsible for the constitutive local expression of antimicrobial peptides cecropin and drosomycin in a tissue-specific manner. These results suggest that certain epithelial tissues have evolved a unique constitutive innate immune strategy by recruiting a developmental "master control" gene.
- Appears in Collections:
- 일반대학원 > 바이오융합과학과 > Journal papers
- Files in This Item:
homeobox gene.pdf(828.62 kB)
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.