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The Homeobox Gene Caudal Regulates Constitutive Local Expression of Antimicrobial Peptide Genes in Drosophila Epithelia

Title
The Homeobox Gene Caudal Regulates Constitutive Local Expression of Antimicrobial Peptide Genes in Drosophila Epithelia
Authors
Ryu J.-H.Nam K.-B.Oh C.-T.Nam H.-J.Kim S.-H.Yoon J.-H.Seong J.-K.Yoo M.-A.Jang I.-H.Brey P.T.Lee W.-J.
Ewha Authors
이원재
Issue Date
2004
Journal Title
Molecular and Cellular Biology
ISSN
0270-7306JCR Link
Citation
Molecular and Cellular Biology vol. 24, no. 1, pp. 172 - 185
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
In Drosophila melanogaster, although the NF-κB transcription factors play a pivotal role in the inducible expression of innate immune genes, such as antimicrobial peptide genes, the exact regulatory mechanism of the tissue-specific constitutive expression of these genes in barrier epithelia is largely unknown. Here, we show that the Drosophila homeobox gene product Caudal functions as the innate immune transcription modulator that is responsible for the constitutive local expression of antimicrobial peptides cecropin and drosomycin in a tissue-specific manner. These results suggest that certain epithelial tissues have evolved a unique constitutive innate immune strategy by recruiting a developmental "master control" gene.
DOI
10.1128/MCB.24.1.172-185.2004
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일반대학원 > 바이오융합과학과 > Journal papers
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