Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김원기 | - |
dc.date.accessioned | 2017-01-05T02:01:11Z | - |
dc.date.available | 2017-01-05T02:01:11Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.other | OAK-1814 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233657 | - |
dc.description.abstract | We examined the effects of the antioxidant propolis on seizures induced by kainic acid (KA). Sprague-Dawley rats received propolis (75 and 150 mg/kg, p.o.) five times at 12 h intervals. KA (10 mg/kg, i.p.) was injected 1 h after the last propolis treatment. Pretreatment with propolis significantly attenuated KA-induced seizures and KA-induced increases in hippocampal AP-1 DNA binding activity in a dose-dependent manner. KA induced increases in the levels of malondialdehyde and protein carbonyl, and a decrease in the ratio of GSH/GSSG. These oxidative stresses and neuronal degenerations were significantly attenuated by pretreatment with propolis. The neuroprotective effects of propolis appeared to be counteracted by adenosine receptor antagonists [A 1 antagonist, 8-cyclopentyl-1,3-dimethylxanthine (25 or 50 μg/kg) ; A2A antagonist, 1,3,7-trimethyl-8-(3-chlorostyryl)xanthine (0.5 or 1 mg/kg); and A2B antagonist, alloxazine (1.5 or 3.0 mg/kg)]. However, this counteraction was most pronounced in the presence of the A 1 antagonist. Our results suggest that the protective effect of propolis against KA-induced neurotoxic oxidative damage is, at least in part, via adenosine A1 receptor modulation. © 2003 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A1 receptor modulation in the rat | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 355 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 231 | - |
dc.relation.lastpage | 235 | - |
dc.relation.journaltitle | Neuroscience Letters | - |
dc.identifier.doi | 10.1016/j.neulet.2003.10.075 | - |
dc.identifier.wosid | WOS:000188396500019 | - |
dc.identifier.scopusid | 2-s2.0-12144288041 | - |
dc.author.google | Kwon Y.-S. | - |
dc.author.google | Park D.-H. | - |
dc.author.google | Shin E.-J. | - |
dc.author.google | Kwon M.S. | - |
dc.author.google | Ko K.H. | - |
dc.author.google | Kim W.-K. | - |
dc.author.google | Jhoo J.H. | - |
dc.author.google | Jhoo W.-K. | - |
dc.author.google | Wie M.-B. | - |
dc.author.google | Jung B.D. | - |
dc.author.google | Kim H.-C. | - |
dc.contributor.scopusid | 김원기(34770946200) | - |
dc.date.modifydate | 20211210152058 | - |