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Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A1 receptor modulation in the rat
- Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A1 receptor modulation in the rat
- Kwon Y.-S.; Park D.-H.; Shin E.-J.; Kwon M.S.; Ko K.H.; Kim W.-K.; Jhoo J.H.; Jhoo W.-K.; Wie M.-B.; Jung B.D.; Kim H.-C.
- Ewha Authors
- Issue Date
- Journal Title
- Neuroscience Letters
- vol. 355, no. 3, pp. 231 - 235
- SCI; SCIE; SCOPUS
- We examined the effects of the antioxidant propolis on seizures induced by kainic acid (KA). Sprague-Dawley rats received propolis (75 and 150 mg/kg, p.o.) five times at 12 h intervals. KA (10 mg/kg, i.p.) was injected 1 h after the last propolis treatment. Pretreatment with propolis significantly attenuated KA-induced seizures and KA-induced increases in hippocampal AP-1 DNA binding activity in a dose-dependent manner. KA induced increases in the levels of malondialdehyde and protein carbonyl, and a decrease in the ratio of GSH/GSSG. These oxidative stresses and neuronal degenerations were significantly attenuated by pretreatment with propolis. The neuroprotective effects of propolis appeared to be counteracted by adenosine receptor antagonists [A 1 antagonist, 8-cyclopentyl-1,3-dimethylxanthine (25 or 50 μg/kg) ; A2A antagonist, 1,3,7-trimethyl-8-(3-chlorostyryl)xanthine (0.5 or 1 mg/kg); and A2B antagonist, alloxazine (1.5 or 3.0 mg/kg)]. However, this counteraction was most pronounced in the presence of the A 1 antagonist. Our results suggest that the protective effect of propolis against KA-induced neurotoxic oxidative damage is, at least in part, via adenosine A1 receptor modulation. © 2003 Elsevier Ireland Ltd. All rights reserved.
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