View : 14 Download: 0

Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A1 receptor modulation in the rat

Title
Antioxidant propolis attenuates kainate-induced neurotoxicity via adenosine A1 receptor modulation in the rat
Authors
Kwon Y.-S.Park D.-H.Shin E.-J.Kwon M.S.Ko K.H.Kim W.-K.Jhoo J.H.Jhoo W.-K.Wie M.-B.Jung B.D.Kim H.-C.
Ewha Authors
김원기
Issue Date
2004
Journal Title
Neuroscience Letters
ISSN
0304-3940JCR Link
Citation
vol. 355, no. 3, pp. 231 - 235
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We examined the effects of the antioxidant propolis on seizures induced by kainic acid (KA). Sprague-Dawley rats received propolis (75 and 150 mg/kg, p.o.) five times at 12 h intervals. KA (10 mg/kg, i.p.) was injected 1 h after the last propolis treatment. Pretreatment with propolis significantly attenuated KA-induced seizures and KA-induced increases in hippocampal AP-1 DNA binding activity in a dose-dependent manner. KA induced increases in the levels of malondialdehyde and protein carbonyl, and a decrease in the ratio of GSH/GSSG. These oxidative stresses and neuronal degenerations were significantly attenuated by pretreatment with propolis. The neuroprotective effects of propolis appeared to be counteracted by adenosine receptor antagonists [A 1 antagonist, 8-cyclopentyl-1,3-dimethylxanthine (25 or 50 μg/kg) ; A2A antagonist, 1,3,7-trimethyl-8-(3-chlorostyryl)xanthine (0.5 or 1 mg/kg); and A2B antagonist, alloxazine (1.5 or 3.0 mg/kg)]. However, this counteraction was most pronounced in the presence of the A 1 antagonist. Our results suggest that the protective effect of propolis against KA-induced neurotoxic oxidative damage is, at least in part, via adenosine A1 receptor modulation. © 2003 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.neulet.2003.10.075
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE