Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2017-01-05T02:01:10Z | - |
dc.date.available | 2017-01-05T02:01:10Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0365-6233 | - |
dc.identifier.other | OAK-1827 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233651 | - |
dc.description.abstract | A series of styrylquinazoline derivatives (2 a-k) were prepared and evaluated for their inhibiton of prostaglandin E2 (PGE2) production by cyclooxygenase-2 (COX-2). The latter was induced by lipopolysaccharide-stimulated macrophage cells RAW264.7. 3′,4′ -Dihydroxylated styrylquinazolines (2 a-c), 3′-hydroxylated styrylquineizolines (2h, 2i), and 3′-acetoxy-styrylquinazolines (2j, 2k) exhibited good inhibitory effects of PGE2 production by COX-2 with a range of IC50 values of 1.19 ∼ 3.56 μM. The potencies were comparable or better than that of the representative stilbene resveratrol (IC50 = 3.07 μM). These results indicate that styrylquinazolines can be considered as potential resveratrol analogues in the modulation of prostaglandin production by COX-2. | - |
dc.language | English | - |
dc.title | Styrylquinazolines: A New Class of Inhibitors on Prostaglandin E 2 Production in Lipopolysaccharide-activated Macrophage Cells | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 337 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 20 | - |
dc.relation.lastpage | 24 | - |
dc.relation.journaltitle | Archiv der Pharmazie | - |
dc.identifier.doi | 10.1002/ardp.200300791 | - |
dc.identifier.wosid | WOS:000188857200003 | - |
dc.identifier.scopusid | 2-s2.0-1242269414 | - |
dc.author.google | Park J.H. | - |
dc.author.google | Min H.-Y. | - |
dc.author.google | Kim S.S. | - |
dc.author.google | Lee J.Y. | - |
dc.author.google | Lee S.K. | - |
dc.author.google | Lee Y.S. | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |