View : 529 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author곽혜선*
dc.date.accessioned2017-01-05T02:01:06Z-
dc.date.available2017-01-05T02:01:06Z-
dc.date.issued2008*
dc.identifier.issn0378-5173*
dc.identifier.otherOAK-4587*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/233613-
dc.description.abstractThis study aimed to formulate and evaluate nasal delivery systems containing ondansetron hydrochloride. In the in vitro study, the permeation rate with the addition of 10% polyethylene glycol 300 (PEG 300) to aqueous solution containing 0.01% benzalkonium chloride (BC) and 10% sulfobutylether ß-cyclodextrin sodium salt (SBCD) was somewhat more rapid up to 1.5 h compared to the addition of 10% PG. The permeation flux increased as the drug concentration increased regardless of the vehicles used. The addition of nicotinamide or chitosan to aqueous drug solution (40 mg/ml) with 10% PEG 300 and 0.01% BC rather decreased permeation rate and delayed lag time. Even though cyclodextrins including SBCD or dimethyl-ß-cyclodextrin failed to show permeation enhancing effects of ondansetron hydrochloride, the addition of 10% SBCD to aqueous solution containing 10% PEG 300 and 0.01% BC could be a good candidate for ondansetron nasal delivery systems because of its safety profile, stable storage in refrigerator and solubilizing effect. With the above formulation, the nasal delivery system increased AUC0-2 h and Cmax by 2.1 and 1.7 times compared to those of oral delivery, respectively while there was no difference found in AUC0-2 h with intravenous administration. Therefore, the nasal delivery system of ondansetron hydrochloride formulated in this study was feasible for nasal administration. © 2007 Elsevier B.V. All rights reserved.*
dc.languageEnglish*
dc.titleFormulation and evaluation of ondansetron nasal delivery systems*
dc.typeArticle*
dc.relation.issue41276*
dc.relation.volume349*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage101*
dc.relation.lastpage107*
dc.relation.journaltitleInternational Journal of Pharmaceutics*
dc.identifier.doi10.1016/j.ijpharm.2007.07.028*
dc.identifier.wosidWOS:000252942400014*
dc.identifier.scopusid2-s2.0-37349035788*
dc.author.googleCho E.*
dc.author.googleGwak H.*
dc.author.googleChun I.*
dc.date.modifydate20240123100124*
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

BROWSE