Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.date.accessioned | 2017-01-05T02:01:02Z | - |
dc.date.available | 2017-01-05T02:01:02Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.other | OAK-4650 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233575 | - |
dc.description.abstract | The protective properties of irisolidone (a metabolite of kakkalide by intestinal bacteria) against hydrogen peroxide (H2O2) induced cell damage were investigated. Irisolidone was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and the intracellular reactive oxygen species (ROS), thereby preventing lipid peroxidation and DNA damage. Irisolidone inhibited apoptosis in Chinese hamster lung fibroblast (V79-4) cells induced by H2O2 via radical scavenging activity. This was achieved by the activation of the extracellular signal regulated kinase (ERK) and DNA binding activity of activator protein-1 (AP-1) (a downstream transcription factor of ERK) by irisolidone. © 2007 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1133 | * |
dc.relation.lastpage | 1141 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.bmc.2007.10.085 | * |
dc.identifier.wosid | WOS:000253720100008 | * |
dc.identifier.scopusid | 2-s2.0-38849204284 | * |
dc.author.google | Kang K.A. | * |
dc.author.google | Zhang R. | * |
dc.author.google | Piao M.J. | * |
dc.author.google | Ko D.O. | * |
dc.author.google | Wang Z.H. | * |
dc.author.google | Kim B.J. | * |
dc.author.google | Park J.W. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Kim D.H. | * |
dc.author.google | Hyun J.W. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.date.modifydate | 20240118140922 | * |