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dc.contributor.author김희선*
dc.date.accessioned2017-01-05T02:01:02Z-
dc.date.available2017-01-05T02:01:02Z-
dc.date.issued2008*
dc.identifier.issn0968-0896*
dc.identifier.otherOAK-4650*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/233575-
dc.description.abstractThe protective properties of irisolidone (a metabolite of kakkalide by intestinal bacteria) against hydrogen peroxide (H2O2) induced cell damage were investigated. Irisolidone was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and the intracellular reactive oxygen species (ROS), thereby preventing lipid peroxidation and DNA damage. Irisolidone inhibited apoptosis in Chinese hamster lung fibroblast (V79-4) cells induced by H2O2 via radical scavenging activity. This was achieved by the activation of the extracellular signal regulated kinase (ERK) and DNA binding activity of activator protein-1 (AP-1) (a downstream transcription factor of ERK) by irisolidone. © 2007 Elsevier Ltd. All rights reserved.*
dc.languageEnglish*
dc.titleProtective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect*
dc.typeArticle*
dc.relation.issue3*
dc.relation.volume16*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage1133*
dc.relation.lastpage1141*
dc.relation.journaltitleBioorganic and Medicinal Chemistry*
dc.identifier.doi10.1016/j.bmc.2007.10.085*
dc.identifier.wosidWOS:000253720100008*
dc.identifier.scopusid2-s2.0-38849204284*
dc.author.googleKang K.A.*
dc.author.googleZhang R.*
dc.author.googlePiao M.J.*
dc.author.googleKo D.O.*
dc.author.googleWang Z.H.*
dc.author.googleKim B.J.*
dc.author.googlePark J.W.*
dc.author.googleKim H.S.*
dc.author.googleKim D.H.*
dc.author.googleHyun J.W.*
dc.contributor.scopusid김희선(57191372551)*
dc.date.modifydate20240118140922*
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의과대학 > 의학과 > Journal papers
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