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Oxidative stress-related gene interactions with preterm delivery in Korean women

Title
Oxidative stress-related gene interactions with preterm delivery in Korean women
Authors
Suh Y.J.Kim Y.J.Park H.Park E.A.Ha E.H.
Ewha Authors
하은희박은애김영주박혜숙
SCOPUS Author ID
하은희scopus; 박은애scopus; 김영주scopus; 박혜숙scopus
Issue Date
2008
Journal Title
American Journal of Obstetrics and Gynecology
ISSN
0002-9378JCR Link
Citation
vol. 198, no. 5, pp. 5410 - 5410000000
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: We hypothesized that the cytochrome P450IA1 (CYP1A1), glutathione S-transferases μ 1 (GSTM1), and θ 1 (GSTT1) polymorphisms are associated with the risk for preterm delivery. This study was undertaken to identify gene-gene interactions and haplotypes that increase the risk of preterm delivery. Study Design: This case-control study was performed in Korea on 145 women with preterm birth and 120 normal controls. Logistic regression and multifactor dimensionality reduction analysis were used to explore single genes and gene-gene interactions, which have an impact on the risk of preterm delivery, respectively. Results: The GSTM1 null genotype and the interaction between the CYP1A1-I462V and GSTM1 null type conferred a risk of preterm birth. The association between preterm delivery and the CYP1A1-T6235C/I462V haplotype plus GSTM1 null type was verified. Conclusion: The interaction between the CYP1A1-I462V and GSTM1 null genotype were found to increase the risk for preterm birth in Korean women. This finding provides evidence of a gene-gene interaction, which has an impact on preterm delivery. © 2008 Mosby, Inc. All rights reserved.
DOI
10.1016/j.ajog.2007.11.013
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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