Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 하은희 | * |
dc.date.accessioned | 2017-01-05T02:01:52Z | - |
dc.date.available | 2017-01-05T02:01:52Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0167-6806 | * |
dc.identifier.other | OAK-4844 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233484 | - |
dc.description.abstract | Objectives: This study was conducted to evaluate the potential role of CASP8 genetic polymorphisms in the etiology of breast cancer in a case-control study, Korea. Methods: Incident breast cancer cases confirmed histologically (n = 1,599) were recruited from two hospitals in Seoul during 2001-2005. Control subjects (n = 1,536) were selected from the Health Examinee Cohort from Seoul and Gyeonggi Province surrounding Seoul, Korea. Three SNPs (D302H D > H, 5′-UTR C > T, and K337K G > A) were genotyped by the primer extension assay. The CASP8 D302H, which was not polymorphic in 48 samples, was excluded in further genotyping. Odds ratios and 95% confidential intervals (95% CIs) were estimated by unconditional logistic regression model adjusted for age at enrollment, education, age at first full-term pregnancy, cigarette smoking, and family history of breast cancer. Results: The 5′-UTR T allele containing genotypes (CT/TT) were associated with an increased risk of breast cancer, compared with those with the CC genotype (OR = 1.13, 95% CI = 0.95-1.34; and OR = 1.48, 95% CI = 1.04-2.10, respectively; P-trend = 0.02). When stratified by the estrogen and progesterone receptor status, the association between the 5′-UTR T allele and breast cancer risk was prominent in ER(+) and PR(+) cases among pre-menopausal women (OR = 1.31, 95% CI = 1.00-1.72 and OR = 1.40, 95% CI = 1.06-1.85, respectively), whereas the association was found prominent in ER(-) or PR(-) cases (OR = 1.32, 95% CI = 0.93-1.87 and OR = 1.42, 95% CI = 1.04-1.94, respectively) among post-menopausal women. Conclusion: Our results thus suggest that the CASP8 5′-UTR C > T are associated with breast cancer risks and the effect may be modified by estrogen and progesterone receptor status. © 2007 Springer Science+Business Media, LLC. | * |
dc.language | English | * |
dc.title | CASP8 polymorphisms, estrogen and progesterone receptor status, and breast cancer risk | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 110 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 387 | * |
dc.relation.lastpage | 393 | * |
dc.relation.journaltitle | Breast Cancer Research and Treatment | * |
dc.identifier.doi | 10.1007/s10549-007-9730-5 | * |
dc.identifier.wosid | WOS:000256471100021 | * |
dc.identifier.scopusid | 2-s2.0-44849086724 | * |
dc.author.google | Han S. | * |
dc.author.google | Lee K.-M. | * |
dc.author.google | Choi J.-Y. | * |
dc.author.google | Park S.K. | * |
dc.author.google | Lee J.-Y. | * |
dc.author.google | Lee J.E. | * |
dc.author.google | Noh D.-Y. | * |
dc.author.google | Ahn S.-H. | * |
dc.author.google | Han W. | * |
dc.author.google | Kim D.-H. | * |
dc.author.google | Hong Y.-C. | * |
dc.author.google | Ha E. | * |
dc.author.google | Yoo K.-Y. | * |
dc.author.google | Kang D. | * |
dc.contributor.scopusid | 하은희(7003615774) | * |
dc.date.modifydate | 20240415125553 | * |