Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 조인호 | * |
dc.date.accessioned | 2017-01-05T02:01:50Z | - |
dc.date.available | 2017-01-05T02:01:50Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-4893 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233467 | - |
dc.description.abstract | Glucocorticoids stabilize the blood-brain barrier (BBB), leading to attenuation of vasogenic brain edema. However, the action mechanism of glucocorticoids has been poorly elucidated. To elucidate the mechanism, we investigated whether dexamethasone (Dex), a synthetic glucocorticoid hormone, regulates the levels of key permeability regulating factors such as angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor (VEGF) in the three types of cells comprising BBB. Dex increased the level of angiopoietin-1 mRNA and protein and decreased VEGF mRNA and protein in brain astrocytes and pericytes, but not in endothelial cells. The mRNA and protein of angiopoietin-2 were detected only in endothelial cells and not regulated by Dex. The Dex-induced regulation of angiopoietin-1 and VEGF was inhibited by RU486, suggestive of glucocorticoid receptor mediation. The mRNA stability of angiopoietin-1 and VEGF was not changed by Dex treatment, implying that Dex increases angiopoietin-1 and decreases VEGF through transcriptional regulation. This is the first study showing the coordinate regulation of angiopoietin-1 and VEGF by glucocorticoids, suggesting a novel mechanism underlying glucocorticoids-induced stabilization of BBB. © 2008 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | Dexamethasone coordinately regulates angiopoietin-1 and VEGF: A mechanism of glucocorticoid-induced stabilization of blood-brain barrier | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 372 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 243 | * |
dc.relation.lastpage | 248 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2008.05.025 | * |
dc.identifier.wosid | WOS:000256874400043 | * |
dc.identifier.scopusid | 2-s2.0-44649139796 | * |
dc.author.google | Kim H. | * |
dc.author.google | Lee J.M. | * |
dc.author.google | Park J.S. | * |
dc.author.google | Jo S.A. | * |
dc.author.google | Kim Y.-O. | * |
dc.author.google | Kim C.-W. | * |
dc.author.google | Jo I. | * |
dc.contributor.scopusid | 조인호(26643129000;56663841900) | * |
dc.date.modifydate | 20240123112949 | * |